What system may involve allergies to medications and environmental substances?

The correct answer is related to the Allergic/Immunologic system, which encompasses the body's immune responses to various allergens, including medications and environmental substances. This system is specifically designed to identify and combat foreign substances that may harm the body. Allergies occur when the immune system overreacts to normally harmless substances, leading to a range of symptoms.

Medications, such as antibiotics or non-steroidal anti-inflammatory drugs, can provoke allergic reactions in sensitive individuals. Similarly, environmental allergens like pollen, dust mites, or pet dander can elicit immune reactions, resulting in conditions such as asthma or rhinitis.

The other systems listed—Endocrine, Psychiatric, and Integumentary—do not specifically pertain to the immune response associated with allergies. The Endocrine system regulates hormones and metabolism; the Psychiatric system deals with mental health and behavioral issues; and the Integumentary system involves skin and its related functions. These systems may interact with or be affected by allergies but do not directly involve the allergic responses to medications and environmental allergens as the Allergic/Immunologic system does.